Activation of DSB processing requires phosphorylation of CtIP by ATR.

Abstract

DNA double-strand breaks (DSBs) activate a DNA damage response (DDR) that coordinates checkpoint pathways with DNA repair. ATM and ATR kinases are activated sequentially. Homology-directed repair (HDR) is initiated by resection of DSBs to generate 3' single-stranded DNA overhangs. How resection and HDR are activated during DDR is not known, nor are the… (More)
DOI: 10.1016/j.molcel.2012.11.020

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