Activation of DNA Damage Response Pathways during Lytic Replication of KSHV

@inproceedings{Hollingworth2015ActivationOD,
  title={Activation of DNA Damage Response Pathways during Lytic Replication of KSHV},
  author={Robert Hollingworth and George L. Skalka and Grant S. Stewart and Andrew D Hislop and David J. Blackbourn and Roger J. A. Grand and Eric O. Freed},
  booktitle={Viruses},
  year={2015}
}
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of several human malignancies. Human tumour viruses such as KSHV are known to interact with the DNA damage response (DDR), the molecular pathways that recognise and repair lesions in cellular DNA. Here it is demonstrated that lytic reactivation of KSHV leads to activation of the ATM and DNA-PK DDR kinases resulting in phosphorylation of multiple downstream substrates. Inhibition of ATM results in the reduction of overall… CONTINUE READING
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