Activation of Complement by Pigment Epithelium-Derived Factor in Rheumatoid Arthritis.

@article{Vogt2017ActivationOC,
  title={Activation of Complement by Pigment Epithelium-Derived Factor in Rheumatoid Arthritis.},
  author={Leonie M Vogt and Simone Talens and Ewa Kwasniewicz and Carsten Scavenius and Andr{\'e} Struglics and Jan J Enghild and Tore Saxne and Anna M. Blom},
  journal={Journal of immunology},
  year={2017},
  volume={199 3},
  pages={1113-1121}
}
The aim of this study was to identify molecules that trigger complement activation in rheumatic joints. C4d, the final cleavage product of C4 activation, is found in the diseased joint and can bind covalently to complement-activating molecules. By using a highly specific Ab against a cleavage neoepitope in C4d, several molecules that were specifically bound to C4d were identified from pooled synovial fluid (SF) from four rheumatoid arthritis (RA) patients. One of these molecules, pigment… CONTINUE READING
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