Activation of Class II or III Metabotropic Glutamate Receptors Protects Cultured Cortical Neurons Against Excitotoxic Degeneration

@article{Bruno1995ActivationOC,
  title={Activation of Class II or III Metabotropic Glutamate Receptors Protects Cultured Cortical Neurons Against Excitotoxic Degeneration},
  author={Valeria Bruno and Giuseppe Battaglia and Agata Copani and Rona G. Giffard and Giuseppina Raciti and Rocco Raffaele and Haruhiko Shinozaki and Ferdinando Nicoletti},
  journal={European Journal of Neuroscience},
  year={1995},
  volume={7}
}
Trans‐1‐aminocyclopentane‐1,3‐dicarboxylic acid, a mixed agonist of all metabotropic glutamate receptor (mGluR) subtypes, is known to produce either neurotoxic or neuroprotective effects. We have therefore hypothesized that individual mGluR subtypes differentially affect neurodegenerative processes. Selective agonists of subtypes which belong to mGluR class II or III, such as (2s, 1′R,2′R,3′R)‐2‐(2,3‐dicarboxycyclopropyl)‐glycine (DCG‐IV) (specific for subtypes mGluR2 or 3) or L‐2‐amino‐4… Expand
Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures
TLDR
The present data support the possibility that antagonizing group I mGluRs may be a useful strategy for attenuating excitotoxic neuronal death in certain disease states. Expand
Role of Group III Metabotropic Glutamate Receptors in Excitotoxin‐Induced Cerebellar Granule Cell Death
TLDR
It was suggested that the group III metabotropic glutamate receptors were responsible for (1S,3R)‐aminocyclopentane‐1,3‐dicarboxylic acid‐induced death. Expand
mGluR7‐like metabotropic glutamate receptors inhibit NMDA‐mediated excitotoxicity in cultured mouse cerebellar granule neurons
TLDR
The present results add to the hypothesis that presynaptic mGLURs, probably mGluR7, may be the targets of drugs decreasing glutamate release and then neuronal death observed in some pathological situations. Expand
Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones
TLDR
The present data suggest that group I mGluRs exert a positive modulatory action on NMDA responses, probably through activation of PKC, in striatal slices, by utilizing intracellular recordings, both in current‐ and voltage‐clamp mode. Expand
Some Metabotropic Glutamate Receptor Ligands Reduce Kynurenate Synthesis in Rats by Intracellular Inhibition of Kynurenine Aminotransferase II
TLDR
It is concluded that some mGluR ligands act intracellularly, inhibiting KAT II activity and therefore reducing kynurenate formation, and should be taken into consideration when novel mGlam glutamate receptor ligands are developed for the treatment of neurological and psychiatric diseases. Expand
Selective Activation of mGlu4 Metabotropic Glutamate Receptors Is Protective against Excitotoxic Neuronal Death
TLDR
Microdialysis studies showed that intrastriatal infusion of NMDA increased extracellular glutamate levels to a greater extent in −/− than in +/+ mice, supporting the hypothesis that the mGluR4 subtype is necessary for the maintenance of the homeostasis of extrace cellular glutamate levels. Expand
Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures.
TLDR
Results indicate that activation of group III mGu receptors exerts neuroprotective activity against excitotoxic neuronal death in mice exposed to a toxic pulse of N-methyl-D-aspartate. Expand
An activity‐dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors
TLDR
It is concluded that group I mGlu receptors are subjected to an activity‐dependent switch in regulating excitotoxic neuronal death and, therefore, the recent ‘history’ of these receptors is critical for the response to agonists or antagonists. Expand
Neuroprotective activity of metabotropic glutamate receptor ligands.
TLDR
A new generation of pharmacological agents allows a more stringent assessment of the role of individual mGluR-subtypes or groups of receptors in various nervous system disorders, including ischaemia-induced brain damage, traumatic brain injury, Huntington's and Parkinson's-like pathology or epilepsy. Expand
Interaction Between A1 Adenosine and Class II Metabotropic Glutamate Receptors in the Regulation of Purine and Glutamate Release from Rat Hippocampal Slices
TLDR
The evoked release of excitatory amino acids and purines is under an inhibitory control by A1 receptors and class II mGLURs, i.e., mGluR2 or 3, which appear to operate through a common transduction pathway. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 68 REFERENCES
A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord
TLDR
DCG‐IV seems to reduce preferentially transmitter release from primary afferent nerve terminals of newborn rat motoneurones, and has the potential of providing further useful information on the physiological function of metabotropic glutamate receptors. Expand
Attenuation of Excitatory Amino Acid Toxicity by Metabotropic Glutamate Receptor Agonists and Aniracetam in Primary Cultures of Cerebellar Granule Cells
TLDR
It is demonstrated here that the concentration‐dependent stimulation of metabotropic glutamate receptor (mGluR) by the selective agonist trans‐1‐aminocyclopentane‐1, 3‐dicarboxylate or by quisqualate counteracts both glutamate‐ and kainate‐induced neurotoxicity in primary cultures of rat cerebellar granule cells. Expand
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
TLDR
DCG-IV, a potent agonist of subtypes 2 and 3 of metabotropic glutamate receptors (mGluR2 or 3), protected cultured cortical neurons against excitotoxicity induced either by a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. Expand
Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.
  • J. Koh, E. Palmer, C. Cotman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
Concomitant activation of the ACPD receptor may serve as a protective mechanism against neurotoxicity that could be produced by brief intense NMDA receptor activation during normal or abnormal brain function. Expand
Activation of a Large‐conductance Ca2+‐Dependent K+ Channel by Stimulation of Glutamate Phosphoinositide‐coupled Receptors in Cultured Cerebellar Granule Cells
TLDR
The most likely hypothesis is that the second messenger system inositol 1,4,5‐triphosphate (IP3)‐Ca2+ was involved in the coupling process and possesses properties similar to those of the so‐called ‘big K+ channel’ described in other preparations. Expand
Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture.
  • D. Hartley, D. Choi
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1989
TLDR
The present study explored the neuroprotective efficacy of delayed manipulations performed after completion of an excitotoxic insult by finding that cultured murine cortical neurons that would otherwise die after exposure to NMDA or glutamate could be rescued by the late addition of NMDA antagonists to the bathing medium. Expand
The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury.
TLDR
Intrastriatal stereotaxic injection of 1S,3R-ACPD produced little brain injury as assessed by hemispheric weight disparities, but markedly potentiated N-methyl-D-aspartate (NMDA)-, but not alpha-amino-3-hydroxy-5- methyl-4-isoxazoleproprionic acid (AMPA)-, mediated brain injury. Expand
Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4
The metabotropic glutamate receptors are coupled to intracellular signal transduction via G-proteins and consist of a family of at least five different subtypes, termed mGluR1-mGluR5. We studied theExpand
Metabotropic glutamate receptors and neuronal toxicity.
TLDR
A role for metabotropic receptors in the mechanism of neuronal degeneration has been suggested and the problem of toxic effects of quisqualate in hippocampal slices and cultured cortical neurons is addressed. Expand
Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity.
TLDR
The interaction between metabotropic and ionotropic glutamate receptors may, therefore, be considered an important target for in vivo pharmacological neuroprotection. Expand
...
1
2
3
4
5
...