Activation of Cl− channels by avermectin in rat cultured hippocampal neurons

@article{Schnrock1993ActivationOC,
  title={Activation of Cl− channels by avermectin in rat cultured hippocampal neurons},
  author={Beate Sch{\"o}nrock and Joachim Bormann},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1993},
  volume={348},
  pages={628-632}
}
The actions of the insecticide avermectin (AVM) were studied in rat cultured hippocampal neurons with patch-clamp techniques. Application of micromolar concentrations of AVM to voltage-clamped cells gave rise to whole-cell currents, which showed a slow time-course of activation in the order of 10 s, and wash-out periods of typically 20 min. Dose-response… CONTINUE READING