Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells.

@article{Sudo2001ActivationOC,
  title={Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells.},
  author={Tamotsu Sudo and Yasuhiro Ota and Shuji Kotani and Mitsuyoshi Nakao and Yasunari Takami and Shunichi Takeda and Hideyuki Saya},
  journal={The EMBO journal},
  year={2001},
  volume={20 22},
  pages={6499-508}
}
Anaphase-promoting complex (APC) is activated by two regulatory proteins, Cdc20 and Cdh1. In yeast and Drosophila, Cdh1-dependent APC (Cdh1-APC) activity targets mitotic cyclins from the end of mitosis to the G1 phase. To investigate the function of Cdh1 in vertebrate cells, we generated clones of chicken DT40 cells disrupted in their Cdh1 loci. Cdh1 was dispensable for viability and cell cycle progression. However, similarly to yeast and Drosophila, loss of Cdh1 induced unscheduled… CONTINUE READING

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