Activation of Ca2+- and cAMP-sensitive K+ channels in murine colonic epithelia by 1-ethyl-2-benzimidazolone.

@article{Cuthbert1999ActivationOC,
  title={Activation of Ca2+- and cAMP-sensitive K+ channels in murine colonic epithelia by 1-ethyl-2-benzimidazolone.},
  author={Alan W. Cuthbert and Margaret E. Hickman and Peter Thorn and Lesley J. MacVinish},
  journal={American journal of physiology. Cell physiology},
  year={1999},
  volume={277 1},
  pages={C111-C120}
}
1-Ethyl-2-benzimidazolone (EBIO) caused a sustained increase in electrogenic Cl- secretion in isolated mouse colon mucosae, an effect reduced by blocking basolateral K+ channels. The Ca2+-sensitive K+ channel blocker charybdotoxin (ChTX) and the cAMP-sensitive K+channel blocker 293B were more effective when the other had been added first, suggesting that both types of K+ channel were activated. EBIO did not cause Cl- secretion in cystic fibrosis (CF) colonic epithelia. In apically permeabilized… CONTINUE READING

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