Activation of Ca2+-Dependent K+ Channels Contributes to Rhythmic Firing of Action Potentials in Mouse Pancreatic β Cells

@article{Gpel1999ActivationOC,
  title={Activation of Ca2+-Dependent K+ Channels Contributes to Rhythmic Firing of Action Potentials in Mouse Pancreatic β Cells},
  author={Sven O. G{\"o}pel and Takahiro Kanno and Sebastian Barg and Lena Eliasson and Juris Galvanovskis and Erik Renstr{\"o}m and Patrik Rorsman},
  journal={The Journal of General Physiology},
  year={1999},
  volume={114},
  pages={759 - 770}
}
We have applied the perforated patch whole-cell technique to beta cells within intact pancreatic islets to identify the current underlying the glucose-induced rhythmic firing of action potentials. Trains of depolarizations (to simulate glucose-induced electrical activity) resulted in the gradual (time constant: 2.3 s) development of a small (<0.8 nS) K(+) conductance. The current was dependent on Ca(2+) influx but unaffected by apamin and charybdotoxin, two blockers of Ca(2+)-activated K… CONTINUE READING
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