Activation of Ca(2+)-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca(2+) release.

@article{Aydin2007ActivationOC,
  title={Activation of Ca(2+)-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca(2+) release.},
  author={Jan Aydin and Topi Korhonen and Pasi Tavi and David G. Allen and H{\aa}kan Westerblad and Joseph D. Bruton},
  journal={Acta physiologica},
  year={2007},
  volume={191 2},
  pages={131-7}
}
AIM To investigate the importance and contribution of calmodulin-dependent protein kinase II (CaMKII) activity on sarcoplasmic reticulum (SR) Ca(2+)-release in response to different work intensities in single, intact muscle fibres. METHODS CaMKII activity was blocked in single muscle fibres using either the inhibitory peptide AC3-I or the pharmacological inhibitor KN-93. The effect on tetanic force production and [Ca(2+)](i) was determined during work of different intensities. The activity of… CONTINUE READING

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