Activation of CPP32 during apoptosis of neurons and astrocytes.

@article{Keane1997ActivationOC,
  title={Activation of CPP32 during apoptosis of neurons and astrocytes.},
  author={Robert W. Keane and Anu Srinivasan and L. M. Foster and Maria Pia Testa and T{\~o}nis Ord and Doris Nonner and Hong-gang Wang and John C. Reed and Dale E. Bredesen and Ceren Kayalar},
  journal={Journal of neuroscience research},
  year={1997},
  volume={48 2},
  pages={168-80}
}
Members of the interleukin-1 beta-converting enzyme (ICE)/CED-3 protease family have been implicated in apoptosis in both vertebrates and invertebrates. Using primary culture methods, we report that neurons and astrocytes require the activity of the ICE/CED-3 family of proteases to undergo apoptosis induced by staurosporine, ceramide, and serum-free media. We show that specific inhibitors of ICE/CED-3 proteases can inhibit apoptosis and that cytosolic fractions from apoptosing neurons, but not… CONTINUE READING

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