Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis.

@article{Flamand1998ActivationOC,
  title={Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis.},
  author={Louis Flamand and Richard W. Crowley and Paolo Lusso and Sandra Colombini-Hatch and David M Margolis and Robert C. Gallo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 6},
  pages={3111-6}
}
T cell activation through the T cell receptor is necessary to achieve a specific and effective immune response. We report here that stimulation of CD8+ T cells through the T cell receptor complex leads to de novo expression of the CD4 antigen on the cell surface that results in susceptibility of CD8+ T cells to HIV infection. In addition, activation of peripheral blood mononuclear cells from HIV-infected individuals results in the appearance of double-positive CD4+/CD8+ T cells, which become… CONTINUE READING
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Flamand et al

  • G. Pantaleo, H. Soudeyns, +9 authors 9848–9853. 3116 Medical Sciences
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

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