Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma.

@article{Robinson1993ActivationOC,
  title={Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma.},
  author={D Robinson and Qutayba A Hamid and Andrew M Bentley and Sun Ying and Antony B. Kay and Stephen R. Durham},
  journal={The Journal of allergy and clinical immunology},
  year={1993},
  volume={92 2},
  pages={313-24}
}
BACKGROUND We have examined whether the local eosinophilia provoked by inhalational allergen challenge of patients with atopic asthma is associated with the appearance, in vivo, of activated TH2-type T helper lymphocytes. METHODS Fifteen patients with atopic asthma had bronchial wash and bronchoalveolar lavage (BAL) 24 hours after allergen or diluent challenge separated by at least 21 days. RESULTS There was an increase in eosinophils in both bronchial wash (p = 0.01) and BAL (p = 0.02… CONTINUE READING
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