Activation of Brain Acetylcholine Receptors by Neuromuscular Blocking Drugs: A Possible Mechanism of Neurotoxicity

@article{Cardone1994ActivationOB,
  title={Activation of Brain Acetylcholine Receptors by Neuromuscular Blocking Drugs: A Possible Mechanism of Neurotoxicity},
  author={C. Cardone and J. Szenohradszky and S. Yost and P. Bickler},
  journal={Anesthesiology},
  year={1994},
  volume={80},
  pages={1155–1161}
}
  • C. Cardone, J. Szenohradszky, +1 author P. Bickler
  • Published 1994
  • Medicine
  • Anesthesiology
  • Background:Neuromuscular blocking drugs cause excitement and seizures when introduced Into the central nervous system. We examined the possibility that these drugs produce paradoxical activation of acetylcholine or glutamate receptors, the chief types of brain receptors involved in excitatory neurotransmission. Methods:Because activation of central glutamate or acetylcholine receptors causes calcium influx into postsynaptic neurons, we measured intracellular calcium concentration ([Ca2+]1) as… CONTINUE READING
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