Activation of Akt predicts poor outcome in neuroblastoma.

  title={Activation of Akt predicts poor outcome in neuroblastoma.},
  author={Daniela Opel and Christopher Poremba and Thorsten Simon and K -M Debatin and Simone Fulda},
  journal={Cancer research},
  volume={67 2},
Whereas aberrant activation of the phosphatidylinositol 3'-kinase (PI3K)/Akt pathway, a key survival cascade, has previously been linked to poor prognosis in several human malignancies, its prognostic effect in neuroblastoma has not yet been explored. We therefore investigated the phosphorylation status of Akt, S6 ribosomal protein as target of mammalian target of rapamycin, and extracellular signal-regulated kinase (ERK) in 116 primary neuroblastoma samples by tissue microarray and its… CONTINUE READING
101 Citations
47 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 101 extracted citations


Publications referenced by this paper.
Showing 1-10 of 47 references

Neuroblastoma : current drug therapy recommendations as part of the total treatment approach

  • F Berthold, B Hero
  • Drugs
  • 2000
Highly Influential
9 Excerpts

Similar Papers

Loading similar papers…