Activation of Akt as a mechanism for tumor immune evasion.

  title={Activation of Akt as a mechanism for tumor immune evasion.},
  author={Kyung Hee Noh and Tae Heung Kang and Jin Hee Kim and Sara Isabel Pai and Ken Y. Lin and Chien-fu Hung and T. -C Wu and Tae Woo Kim},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={17 3},
Immune evasion is an important reason why the immune system cannot control tumor growth. To elucidate the mechanism for tumor immune evasion, we generated an immune-resistant human papillomavirus type 16 (HPV-16) E7-expressing tumor cell line by subjecting a susceptible tumor cell line to multiple rounds of in vivo immune selection with an E7-specific vaccine. Comparison of parental and immune-resistant tumors revealed that Akt is highly activated in the immune-resistant tumors. Retroviral… CONTINUE READING


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