Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression.

@article{Hutchinson2001ActivationOA,
  title={Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression.},
  author={John N. Hutchinson and Jianmin Jin and Robert Cardiff and James R Woodgett and William J. Muller},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 6},
  pages={2203-12}
}
Activation of Akt by the phosphatidylinositol 3'-OH kinase (PI3K) results in the inhibition of proapoptotic signals and the promotion of survival signals (L. P. Kane et al., Curr. Biol. 9:601-604, 1999; G. J. Kops et al., Nature 398:630-634, 1999). Evidence supporting the importance of the PI3K/Akt signaling pathway in tumorigenesis stems from experiments with transgenic mice bearing polyomavirus middle T antigen under the control of the mouse mammary tumor virus long terminal repeat promoter… CONTINUE READING

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