Activation of Akt/mTOR Pathway Is Associated with Poor Prognosis of Nasopharyngeal Carcinoma

@inproceedings{Wang2014ActivationOA,
  title={Activation of Akt/mTOR Pathway Is Associated with Poor Prognosis of Nasopharyngeal Carcinoma},
  author={Weiyuan Wang and Qiuyuan Wen and Lina Xu and Guiyuan Xie and Jiao Li and Jiadi Luo and Shuzhou Chu and Lei Shi and Donghai Huang and Jinghe Li and Songqing Fan},
  booktitle={PloS one},
  year={2014}
}
Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck region, which frequently occurs in Southeast Asia, especially in the south of China. It is known that the mammalian target of rapamycin (mTOR) pathway plays a central role in regulating cellular functions, including proliferation, growth, survival, mobility, and angiogenesis. Aberrant expression of the mTOR signaling pathway molecules has been found in many types of cancer. However, whether the alterations of p-Akt, p… CONTINUE READING