Activation of Akt/FoxO and inactivation of MEK/ERK pathways contribute to induction of neuroprotection against transient global cerebral ischemia by delayed hypoxic postconditioning in adult rats.

@article{Zhan2012ActivationOA,
  title={Activation of Akt/FoxO and inactivation of MEK/ERK pathways contribute to induction of neuroprotection against transient global cerebral ischemia by delayed hypoxic postconditioning in adult rats.},
  author={Lixuan Zhan and Danfang Li and Donghai Liang and Baoxing Wu and Pingping Zhu and Yanmei Wang and Weiwen Sun and En Xu},
  journal={Neuropharmacology},
  year={2012},
  volume={63 5},
  pages={873-82}
}
Ischemic postconditioning, a series of mechanical interruptions of blood flow immediately after reperfusion, has been described in brain studies. However, hypoxic postconditioning (HPC) has never been reported in transient global cerebral ischemia (tGCI) adult rat model. The purpose of this study is to explore the effects of neuroprotection by delayed HPC against tGCI in adult rats and investigate underlying mechanisms involving the Akt/Forkhead transcription factor, class O (FoxO) and mitogen… CONTINUE READING
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