Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways

@inproceedings{KuanYu2017ActivationOA,
  title={Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways},
  author={I Kuan-Yu and Yi-Shu Huang and Ching-Hsun Hu and Wen-Yi Issac Tseng and Chia-Hsin Cheng and Martin Stacey and Siamon Gordon and Gin-Wen Chang and H Lin},
  booktitle={Front. Immunol.},
  year={2017}
}
EMR2/ADGRE2 is a human myeloid-restricted adhesion G protein-coupled receptor critically implicated in vibratory urticaria, a rare type of allergy caused by vibration-induced mast cell activation. In addition, EMR2 is also highly expressed by monocyte/macrophages and has been linked to neutrophil migration and activation. Despite these findings, little is known of EMR2-mediated signaling and its role in myeloid biology. In this report, we show that activation of EMR2 via a receptor-specific… CONTINUE READING
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