Activation of Adenosine A1 Receptors Reduces Anxiety-Like Behavior During Acute Ethanol Withdrawal (Hangover) in Mice

@article{Prediger2006ActivationOA,
  title={Activation of Adenosine A1 Receptors Reduces Anxiety-Like Behavior During Acute Ethanol Withdrawal (Hangover) in Mice},
  author={Rui Daniel Prediger and George E. Da Silva and Luciano C. Batista and Alvorita Leite Bittencourt and Reinaldo Naoto Takahashi},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={2210-2220}
}
Elevated signs of anxiety are observed in both humans and rodents during withdrawal from chronic as well as acute ethanol exposure, and it represents an important motivational factor for ethanol relapse. Several reports have suggested the involvement of brain adenosine receptors in different actions produced by ethanol such as motor incoordination and hypnotic effects. In addition, we have recently demonstrated that adenosine A1 receptors modulate the anxiolytic-like effect induced by ethanol… CONTINUE READING
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