Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries.

@article{Matrougui1999ActivationOA,
  title={Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries.},
  author={Khalid Matrougui and Laurent Loufrani and Christophe Heymes and Bernard I L{\'e}vy and Daniel Henrion},
  journal={Hypertension},
  year={1999},
  volume={34 4 Pt 1},
  pages={659-65}
}
Pressure-induced tone (myogenic, MT) and flow (shear stress)-induced dilation (FD) are potent modulators of resistance artery tone. We tested the hypothesis that locally produced angiotensin II interacts with MT and FD. Rat mesenteric resistance arteries were perfused in situ. Arterial diameter was measured by intravital microscopy after a bifurcation on 2 distal arterial branches equivalent in size (150 microm, n=7 per group). One was ligated distally and thus submitted to pressure only (MT… CONTINUE READING

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