Activation of AP-1 and SP1 correlates with wound growth factor gene expression in glucan-treated human fibroblasts.

@article{Wei2002ActivationOA,
  title={Activation of AP-1 and SP1 correlates with wound growth factor gene expression in glucan-treated human fibroblasts.},
  author={Duo Wei and David Williams and William A. Browder},
  journal={International immunopharmacology},
  year={2002},
  volume={2 8},
  pages={1163-72}
}
Glucan is a natural product immunomodulator that has been reported to enhance early wound repair. The mechanism of glucan-stimulated wound repair was thought to be indirect via macrophage release of wound growth factors. However, recent data indicate that there are glucan-specific receptors on human fibroblasts that can modulate cellular function following interaction with the glucan ligand. In this study we examined the effect of glucan on activation of the transcription factors activator… CONTINUE READING