Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

@inproceedings{Wu2015ActivationOA,
  title={Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo},
  author={Yongzhen Wu and Ping Song and Wencheng Zhang and Junhui Liu and Xiaoyan Dai and Zhaoyu Liu and Qiulun Lu and Changhan Ouyang and Zhonglin Xie and Zhengxing Zhao and Xiaozhen Zhuo and Benoit Viollet and Marc Foretz and Jiliang Wu and Zuyi Yuan and Ming-Hui Zou},
  booktitle={Nature Medicine},
  year={2015}
}
Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. However, the mechanisms behind these effects are unclear. Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase α2 (AMPKα2) in adipocytes, which in turn phosphorylates MAP kinase phosphatase-1 (MKP1) at serine 334, initiating its proteasome-dependent degradation. The nicotine-dependent… CONTINUE READING
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