Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle.

  title={Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle.},
  author={W. Winder and B. Holmes and D. S. Rubink and E. B. Jensen and M. Chen and J. Holloszy},
  journal={Journal of applied physiology},
  volume={88 6},
  • W. Winder, B. Holmes, +3 authors J. Holloszy
  • Published 2000
  • Biology, Medicine
  • Journal of applied physiology
  • Muscle contraction causes an increase in activity of 5'-AMP-activated protein kinase (AMPK). This study was designed to determine whether chronic chemical activation of AMPK will increase mitochondrial enzymes, GLUT-4, and hexokinase in different types of skeletal muscle of resting rats. In acute studies, rats were subcutaneously injected with either 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR; 1 mg/g body wt) in 0.9% NaCl or with 0.9% NaCl alone and were then anesthetized for… CONTINUE READING
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