Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle.

@article{Winder2000ActivationOA,
  title={Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle.},
  author={William W. Winder and Burton F. Holmes and D. S. Rubink and Ellis B. Jensen and M M Chen and John O. Holloszy},
  journal={Journal of applied physiology},
  year={2000},
  volume={88 6},
  pages={
          2219-26
        }
}
Muscle contraction causes an increase in activity of 5'-AMP-activated protein kinase (AMPK). This study was designed to determine whether chronic chemical activation of AMPK will increase mitochondrial enzymes, GLUT-4, and hexokinase in different types of skeletal muscle of resting rats. In acute studies, rats were subcutaneously injected with either 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR; 1 mg/g body wt) in 0.9% NaCl or with 0.9% NaCl alone and were then anesthetized for… 

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