Activation of ADF/cofilin by phosphorylation-regulated Slingshot phosphatase is required for the meiotic spindle assembly in Xenopus laevis oocytes

@inproceedings{Iwase2013ActivationOA,
  title={Activation of ADF/cofilin by phosphorylation-regulated Slingshot phosphatase is required for the meiotic spindle assembly in Xenopus laevis oocytes},
  author={Shohei Iwase and Ryuhei Sato and Pieter-Jan De Bock and Kris Gevaert and Saburo Fujiki and Toshinobu Tawada and Miyako Kuchitsu and Yuka Yamagishi and Shoichiro Ono and Hiroshi Abe},
  booktitle={Molecular biology of the cell},
  year={2013}
}
We identify Xenopus ADF/cofilin (XAC) and its activator, Slingshot phosphatase (XSSH), as key regulators of actin dynamics essential for spindle microtubule assembly during Xenopus oocyte maturation. Phosphorylation of XSSH at multiple sites within the tail domain occurs just after germinal vesicle breakdown (GVBD) and is accompanied by dephosphorylation of… CONTINUE READING