Corpus ID: 20221441

Activation of A2A adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophils.

@article{Sullivan2004ActivationOA,
  title={Activation of A2A adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophils.},
  author={Gail W. Sullivan and David D. Lee and William G. Ross and Jeffrey A. DiVietro and Courtney M. Lappas and Michael B. Lawrence and Joel Linden},
  journal={Journal of leukocyte biology},
  year={2004},
  volume={75 1},
  pages={
          127-34
        }
}
  • Gail W. Sullivan, David D. Lee, +4 authors Joel Linden
  • Published 2004
  • Medicine
  • Journal of leukocyte biology
  • The alpha 4/beta 1 integrin very late antigen-4 (CD49d/CD29) is up-regulated on circulating neutrophils of septic patients. Although no individual agent mimics this effect of sepsis, we now report that following priming of human neutrophils with lipopolysaccharide or tumor necrosis factor alpha (TNF-alpha), addition of formyl-Met-Leu-Phe (fMLP) results in a "stimulated", sepsis-like, four- to fivefold rise in CD49d expression. TNF/fMLP stimulation also produced a similar increase in CD49d… CONTINUE READING

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