Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells.

@article{Reshkin2000ActivationOA,
  title={Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells.},
  author={Stephan Joel Reshkin and Liliana Guerra and Anna Bagorda and Lucantonio Debellis and Rosetta Cardone and Allen Hon-Lun Li and Kenneth A. Jacobson and Valeria Casavola},
  journal={The Journal of membrane biology},
  year={2000},
  volume={178 2},
  pages={103-13}
}
We have previously demonstrated that in A(6) renal epithelial cells, a commonly used model of the mammalian distal section of the nephron, adenosine A(1) and A(2A) receptor activation modulates sodium and chloride transport and intracellular pH (Casavola et al., 1997). Here we show that apical addition of the A(3) receptor-selective agonist, 2-chloro-N(6)-(3-iodobenzyl)-adenosine-5'-methyluronamide (Cl-IB-MECA) stimulated a chloride secretion that was mediated by calcium- and cAMP-regulated… CONTINUE READING

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