Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.

@article{Werz2002ActivationO5,
  title={Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.},
  author={Oliver Werz and Eva Buerkert and Bengt Samuelsson and Olof R{\aa}dmark and Dieter Steinhilber},
  journal={Blood},
  year={2002},
  volume={99 3},
  pages={1044-52}
}
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. This study showed that various forms of cell stress, such as chemical stress (sodium arsenite), osmotic stress, or heat shock lead to substantial formation of 5-LO products in freshly isolated human polymorphonuclear leukocytes (PMNLs), when exogenous arachidonic acid (10 microM) was present. In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activated… CONTINUE READING
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