Activation of 5-lipoxygenase after oxygen-glucose deprivation is partly mediated via NMDA receptor in rat cortical neurons.

@article{Ge2006ActivationO5,
  title={Activation of 5-lipoxygenase after oxygen-glucose deprivation is partly mediated via NMDA receptor in rat cortical neurons.},
  author={Qiu-fu Ge and Er-qing Wei and Wei-ping Zhang and Xin Hu and Xiao-jia Huang and Lei Zhang and Ying Song and Zhen-qiu Ma and Zhong Chen and Jianhong Luo},
  journal={Journal of neurochemistry},
  year={2006},
  volume={97 4},
  pages={992-1004}
}
5-Lipoxygenase (5-LOX) is the enzyme metabolizing arachidonic acid to produce pro-inflammatory leukotrienes. We have reported that 5-LOX is translocated to the nuclear envelope after ischemic-like injury in PC12 cells. In the present study, we determined whether 5-LOX is activated (translocation and production of leukotrienes) after oxygen-glucose deprivation (OGD) in primary rat cortical neurons; if so, whether this activation is mediated by NMDA receptor. After OGD, 5-LOX was translocated to… CONTINUE READING

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