Activation of 5-hydroxytryptamine1B/1D/1F receptors as a mechanism of action of antimigraine drugs

@article{RamrezRosas2013ActivationO5,
  title={Activation of 5-hydroxytryptamine1B/1D/1F receptors as a mechanism of action of antimigraine drugs},
  author={Martha B. Ram{\'i}rez Rosas and Sieneke Labruijere and Carlos M. Villal{\'o}n and Antoinette Maassen Vandenbrink},
  journal={Expert Opinion on Pharmacotherapy},
  year={2013},
  volume={14},
  pages={1599 - 1610}
}
Introduction: The introduction of the triptans (5-hydroxytryptamine (5-HT)1B/1D receptor agonists) was a great improvement in the acute treatment of migraine. However, shortcomings of the triptans have prompted research on novel serotonergic targets for the treatment of migraine. Areas covered: In this review the different types of antimigraine drugs acting at 5-HT receptors, their discovery and development are discussed. The first specific antimigraine drugs were the ergot alkaloids… 

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