Activation of 5-HT6 receptors facilitates attentional set shifting

  title={Activation of 5-HT6 receptors facilitates attentional set shifting},
  author={Katherine E. Burnham and Mark G Baxter and John R. Bainton and Eric Southam and Lee A. Dawson and D. M. Bannerman and Trevor Sharp},
Prefrontal cortex (PFC)-dependent executive function is disrupted in a range of psychiatric disorders and can be modelled in non-human primates and rodents using attentional set-shifting paradigms. There are few current pharmacological strategies for enhancing attentional set shifting, although the PFC is rich in relevant neurotransmitter targets, including 5-hydroxytryptamine (5-HT). Although 5-HT depletion studies do not support a role for 5-HT in attentional set shifting, the effect of 5-HT… CONTINUE READING