Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens

  title={Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens},
  author={Jianping Chen and Herman M. van Praag and Eliot L. Gardner},
  journal={Brain Research},
The serotonin-3 (5-HT3) agonist 1-phenylbiguanide (0.1-1.0 mM in perfusate) caused a robust, dose-dependent enhancement of extracellular dopamine content in nucleus accumbens as measured by in vivo microdialysis. This action was antagonized by co-perfusion of the 5-HT3 antagonists zacopride and GR38032F (1 mM in perfusate). Similar effects were observed in 5-HT-denervated rats. These findings suggest that there is a potent modulation of dopamine (DA) release in the nucleus accumbens mediated… Expand
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In the DA-rich nucleus accumbens, 5-HT1B/1D receptors are not involved in the modulation ofDA release during normal tonic or basal conditions but may take part in the regulation of DA release when synaptic 5- HT levels are very high. Expand
Activation of 5-HT2A/2C receptors within the nucleus accumbens increases local dopaminergic transmission
  • Q. Yan
  • Medicine, Biology
  • Brain Research Bulletin
  • 2000
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Serotonin-3 receptor and ethanol-stimulated dopamine release in the nucleus accumbens
The results support an involvement of 5-HT3 receptors in regulating DA release in the Acb, and also in mediating ethanol-induced DA release. Expand
Antagonism of 5-Hydroxytryptamine4 Receptors Attenuates Hyperactivity Induced by Cocaine: Putative Role for 5-Hydroxytryptamine4 Receptors in the Nucleus Accumbens Shell
The localization of 5-hydroxytryptamine4(5-HT4) receptors suggests their role in the regulation of dopamine (DA) neurotransmission, a speculation that has been supported by neurochemical studies.Expand
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The data suggest that 5-HT(4) receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders. Expand
Is the potent 5-HT1A receptor agonist, alnespirone (S-20499), affecting dopaminergic systems in the rat brain?
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Activation of 5-HT3 receptors enhances the electrically evoked release of [3H]noradrenaline in rat brain limbic structures.
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Activation of 5-HT(1B/1D) receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study.
  • Q. Yan, S. Yan
  • Chemistry, Medicine
  • European journal of pharmacology
  • 2001
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M100,907, a selective 5-HT2A antagonist, attenuates dopamine release in the rat medial prefrontal cortex
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5-HT3 receptor mediated dopamine release in the nucleus accumbens during withdrawal from continuous cocaine
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Inhibition of the electrically induced release of [3H]dopamine by serotonin from superfused rat striatal slices
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Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release.
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Influence of antipsychotics on presynaptic receptors modulating the release of dopamine in synaptosomes of the nucleus accumbens of rats
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Phencyclidine (PCP) injected in the nucleus accumbens increases extracellular dopamine and serotonin as measured by microdialysis.
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Effects of the 5‐HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain
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Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding
Direct evidence for the existence of 5-HT3 receptors in rat brain tissue and their distribution is reported, based on high affinity binding of the potent 5- HT3 receptor antagonist 3H-GR65630 to homogenates of rat entorhinal cortex. Expand
Presynaptic Control of the Synthesis and Release of Dopamine from Striatal Synaptosomes: A Comparison Between the Effects of 5‐Hydroxytryptamine, Acetylcholine, and Glutamate
The effects of 5‐HT and glutamate on dopamine synthesis and release by striatal synaptosomes were investigated and compared with the action of acetylcholine, which acts presynaptically on thisExpand
Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species.
There was a close correlation between drug affinities in each area of human brain, and specific binding to homogenates of rat area postrema and vagus nerve was characterised. Expand
The potential anxiolytic activity of GR38032F, a 5‐HT3‐receptor antagonist
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