Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens

@article{Chen1991ActivationO5,
  title={Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens},
  author={Jianping Chen and Herman M. van Praag and Eliot L. Gardner},
  journal={Brain Research},
  year={1991},
  volume={543},
  pages={354-357}
}
The serotonin-3 (5-HT3) agonist 1-phenylbiguanide (0.1-1.0 mM in perfusate) caused a robust, dose-dependent enhancement of extracellular dopamine content in nucleus accumbens as measured by in vivo microdialysis. This action was antagonized by co-perfusion of the 5-HT3 antagonists zacopride and GR38032F (1 mM in perfusate). Similar effects were observed in 5-HT-denervated rats. These findings suggest that there is a potent modulation of dopamine (DA) release in the nucleus accumbens mediated… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
The effect of intraventricular administration of the 5-HT3 receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chronocoulometric study
TLDR
The results suggest that the 2-Me-5HT-induced DA release in the NAc is mediated by 5-HT3 receptors and is dependent upon the impulse flow of DA cells. Expand
Inhibition of the electrically induced release of [3H]dopamine by serotonin from superfused rat striatal slices
TLDR
The present results suggest that serotonin should be added to the list of endogenous substances that can influence dopaminergic transmission in the striatum. Expand
Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release.
TLDR
The results indicate that blockade of 5-HT3 receptors selectively prevents the stimulation of DA release induced by drugs known to stimulate the firing activity of DA neurons. Expand
Influence of antipsychotics on presynaptic receptors modulating the release of dopamine in synaptosomes of the nucleus accumbens of rats
TLDR
The experimental system demonstrated appears to be suitable for characterizing the DA- and serotonin-antagonistic potencies of antipsychotics and other drugs on presynaptic autoreceptors as well as receptors modulating release of DA in the nucleus accumbens. Expand
Phencyclidine (PCP) injected in the nucleus accumbens increases extracellular dopamine and serotonin as measured by microdialysis.
TLDR
Microdialysis suggests that PCP acts in some dopamine terminal regions to increase extracellular dopamine and serotonin in freely moving animals. Expand
Effects of the 5‐HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain
TLDR
It is concluded that the 5‐HT3 receptor antagonist GR38032F, and the neuroleptic agents fluphenazine, sulpiride and haloperidol, can reduce raised mesolimbic dopaminergic activity in the rat and marmoset. Expand
Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding
TLDR
Direct evidence for the existence of 5-HT3 receptors in rat brain tissue and their distribution is reported, based on high affinity binding of the potent 5- HT3 receptor antagonist 3H-GR65630 to homogenates of rat entorhinal cortex. Expand
Presynaptic Control of the Synthesis and Release of Dopamine from Striatal Synaptosomes: A Comparison Between the Effects of 5‐Hydroxytryptamine, Acetylcholine, and Glutamate
The effects of 5‐HT and glutamate on dopamine synthesis and release by striatal synaptosomes were investigated and compared with the action of acetylcholine, which acts presynaptically on thisExpand
Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species.
TLDR
There was a close correlation between drug affinities in each area of human brain, and specific binding to homogenates of rat area postrema and vagus nerve was characterised. Expand
The potential anxiolytic activity of GR38032F, a 5‐HT3‐receptor antagonist
TLDR
It is concluded that GR38032F is potentially a very potent anxiolytic agent without sedative, anticonvulsant or hypnotic activity. Expand
...
1
2
...