Activation of 5-HT2B Receptors in the Medial Amygdala causes Anxiolysis in the Social Interaction Test in the Rat

  title={Activation of 5-HT2B Receptors in the Medial Amygdala causes Anxiolysis in the Social Interaction Test in the Rat},
  author={Mark S. Duxon and Guy A. Kennett and Sean Lightowler and Thomas P Blackburn and Kevin C.F. Fone},

The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats

Probably reflecting its distinctive ability to selectively and preferentially activate pre- versus postsynaptic 5-HT1A receptors, S15535 suppresses hippocampal 5- HT release and displays marked anxiolytic-like effects over a broad dose range in the relative absence of motor perturbation.

Differential roles of amygdaloid nuclei in the anxiolytic- and antidepressant-like effects of the V1b receptor antagonist, SSR149415, in rats

While the antidepressant- like effects of SSR149415 are mediated by different amygdaloid nuclei, its anxiolytic-like effects appear to involve only the basolateral nucleus of the amygdala, adding further evidence to the role of extrahypothalamic vasopressinergic systems in the control of emotional responses.

Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat

Neuronal localization of the 5-HT2 receptor family in the amygdaloid complex

The present review reports data concerning the distribution and the functional roles of the 5-HT2 receptor family in the amygdalar microcircuits, which could play a critical role in the formation of emotional memories.

m-CPP-induced self-grooming is mediated by 5-HT2C receptors

Effects of centrally administered anxiolytic compounds in animal models of anxiety




Effects of the 5‐HT2B receptor agonist, BW 723C86, on three rat models of anxiety

In conclusion, BW 723C86 exerted an appreciable anxiolytic‐like profile in a rat social interaction test, but had a weaker effect in the Geller‐Siefter and was ineffective in the elevated x‐maze test used.

The 5-hydroxytryptamine2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertensive rats.

Significant changes in 5-HT receptor signal transduction in DOCA-salt hypertension are demonstrated, both at the level of the receptor and G protein and may provide one reason why ketanserin has proved to be a relatively ineffective antihypertensive agent in some forms of hypertension.

Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

The affinity of a compound for the 5-HT2F receptor at 37 degrees versus 0 degree was shown to be useful for predicting agonist or antagonist activity, and information is provided about some of the structural requirements for the affinity of certain tryptamines at the 4-HT/1C receptor family.

Axon-sparing lesions of the medial nucleus of the amygdala decrease affiliative behaviors in the prairie vole (Microtus ochrogaster): behavioral and anatomical specificity.

The neural basis of affiliative behavior was examined in the prairie vole, a rodent that exhibits high levels of social contact and paternal behavior, and neurons in the medial nucleus of the amygdala appear to be essential for the normal expression of paternal care in this species.