Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits

@article{Ootsuka2006ActivationO5,
  title={Activation of 5-HT1A receptors in rostral medullary raph{\'e} inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits},
  author={Youichirou Ootsuka and William W Blessing},
  journal={Brain Research},
  year={2006},
  volume={1073},
  pages={252-261}
}

Blockade of 5-HT2A receptors inhibits emotional hyperthermia in mice

TLDR
It is suggested that 5-HT2A receptors play a significant role in mediating hyperthermia, but not tachycardia, during intruder-elicited psychological stress.

Activation of 5-HT1A receptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet.

TLDR
The data are consistent with the hypothesis that neurons expressing 5-HT1A receptors in the medullary raphé facilitate spinal motor circuits involved in shivering, as well as sympathetic stimulation of other thermoregulatory effector mechanisms.

Activation of 5-hydroxytryptamine-1A receptors suppresses cardiovascular responses evoked from the paraventricular nucleus.

TLDR
Results indicate that activation of central 5-HT(1A) receptors located outside the PVN powerfully inhibits the tachycardia and renal sympathoexcitation evoked by stimulation of neurons in the PVn.

5-Hydroxytryptamine inhibits neuronal high-voltage-activated calcium currents in the preoptic anterior hypothalamus via 5-hydroxytryptamine 1 A and 7 receptors

TLDR
5-HT1A and 5-HT7 receptors were suggested to be involved in the 5- HT-induced decrease of HVA calcium currents in PO/AH neurons and might contribute to the hypothermic effects of thermoregulation.

Activation of 5-HT1A receptors in the paragigantocellularis lateralis decreases shivering during cooling in the conscious piglet.

TLDR
Both naturally occurring REM sleep and exogenous activation of 5-HT(1A) receptors in the paragigantocellularis lateralis (PGCL) are associated with a suspension of shivering during cooling, consistent with the hypothesis that 5- HT neurons in the PGCL facilitate oscillating spinal motor circuits involved in shivering but are less involved in modulating sympathetically mediated thermoregulatory mechanisms.

3,4-Methylenedioxymethamphetamine- and 8-Hydroxy-2-di-n-propylamino-tetralin-Induced Hypothermia: Role and Location of 5-Hydroxytryptamine 1A Receptors

TLDR
Although hypothermia mediated by both MDMA and DPAT shares a common dependence on the activation of 5-HT1A receptors, the location of these receptors is different for each drug.

Inhibition of the cardiovascular response to stress by systemic 5-HT1A activation: sympathoinhibition or anxiolysis?

  • D. ViannaP. Carrive
  • Biology, Psychology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2009
TLDR
Doses of 5-HT(1A) agonists, which are just sufficient to produce anxiolysis, are not enough to cause true sympathoinhibition, and the results suggest that 8-OH-DPAT acts preferentially on limbic, rather than central, autonomic sites.

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