Activation of β-catenin by carcinogenic Helicobacter pylori

@inproceedings{Franco2005ActivationO,
  title={Activation of β-catenin by carcinogenic Helicobacter pylori},
  author={Aime T Franco and Dawn A. Israel and M. Kay Washington and U. Hemanth Krishna and James G Fox and Arlin B. Rogers and Andrew S. Neish and Lauren S. Collier-Hyams and Guillermo I Perez-Perez and Masanori Hatakeyama and Robert H. Whitehead and Kristin Gaus and Daniel P. O'Brien and Judith Romero-Gallo and Richard M Peek},
  year={2005}
}
Persistent gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the distal stomach, yet only a fraction of colonized persons ever develop gastric cancer. The H. pylori cytotoxin-associated gene ( cag ) pathogenicity island encodes a type IV secretion system that delivers the bacterial effector CagA into host cells after bacterial attachment, and cag + strains augment gastric cancer risk. A host effector that is aberrantly activated in gastric cancer… CONTINUE READING

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