Activation of αVβ3 on Vascular Cells Controls Recognition of Prothrombin

Abstract

Regulation of vascular homeostasis depends upon collaboration between cells of the vessel wall and blood coagulation system. A direct interaction between integrin a V b 3 on endothelial cells and smooth muscle cells and prothrombin, the pivotal proenzyme of the blood coagulation system, is demonstrated and activation of the integrin is required for receptor… (More)

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@article{Byzova1998ActivationO, title={Activation of αVβ3 on Vascular Cells Controls Recognition of Prothrombin }, author={Tatiana V. Byzova and Edward F Plow}, journal={The Journal of Cell Biology}, year={1998}, volume={143}, pages={2081 - 2092} }