Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved postischemic myocardial performance via inhibiting MMP-2 activation.

@article{Gao2014ActivationO,
  title={Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved postischemic myocardial performance via inhibiting MMP-2 activation.},
  author={Ling Gao and Le Chen and Zhi-Zhen Lu and Hong Xia Gao and Lan Wu and Yi-Xiong Chen and Cai-Mei Zhang and Yu-kun Jiang and Qing Jing and Y Jonathan Zhang and Huang-Tian Yang},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2014},
  volume={306 11},
  pages={H1569-81}
}
Inhibition of matrix metalloproteinases-2 (MMP-2) activation renders cardioprotection from ischemia/reperfusion (I/R) injury; however, the signaling pathways involved have not been fully understood. Intermittent hypobaric hypoxia (IHH) has been shown to enhance myocardial tolerance to I/R injury via triggering intrinsic adaptive responses. Here we investigated whether IHH protects the heart against I/R injury via the regulation of MMP-2 and how the MMP-2 is regulated. IHH (Po2 = 84 mmHg, 4-h… CONTINUE READING
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Protective effects of chronic intermittent hypoxia against myocardial ischemia reperfusion injury

  • H Yang, Y Zhang, ZH Wang, ZN. Zhou
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  • 2012
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