Activation of α1 and α2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells

@article{Nai2010ActivationO,
  title={Activation of α1 and α2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells},
  author={Qiang Nai and Hong Wei Dong and C. Linster and Matthew Ennis},
  journal={Neuroscience},
  year={2010},
  volume={169},
  pages={882-892}
}
The mammalian main olfactory bulb (MOB) receives a dense noradrenergic innervation from the pontine nucleus locus coeruleus that is important for neonatal odor preference learning and odor processing in mature animals. Modulation of GABAergic granule cells (GCs) is thought to play a key role in the net functional impact of norepinephrine (NE) release in the MOB, yet there are few direct studies of the influence of NE on these cells. In the present study we investigated noradrenergic modulation… CONTINUE READING

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