Activation mechanisms of matrix metalloproteinases.

  title={Activation mechanisms of matrix metalloproteinases.},
  author={Hideaki Nagase},
  journal={Biological chemistry},
  volume={378 3-4},
Matrix metalloproteinases (MMPs), also called matrixins, function in the turnover of extracellular matrix components. These enzymes are considered to play important roles in embryo development, morphogenesis and tissue remodeling, and in diseases such as arthritis, periodontitis, glomerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. All MMPs are synthesized as preproenzymes and most of them are secreted from the cells as proenzymes. Thus, the… CONTINUE READING
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