Activation mechanism of the heterodimeric GABA(B) receptor.

@article{Pin2004ActivationMO,
  title={Activation mechanism of the heterodimeric GABA(B) receptor.},
  author={Jean-Philippe Pin and Julie Kniazeff and Virginie Binet and Jianfeng Liu and Damien Maurel and Thierry Galvez and B{\'e}atrice Duthey and Michaela Havlickova and Jaroslav Blahos and Laurent Pr{\'e}zeau and Philippe Rondard},
  journal={Biochemical pharmacology},
  year={2004},
  volume={68 8},
  pages={
          1565-72
        }
}
The GABA(B) receptor was the first heteromeric G-protein coupled receptor (GPCR) identified. Indeed, both GABA(B1) and GABA(B2) subunits appear necessary to get a functional GABA(B) receptor. Soon after the cloning of both subunits, it was demonstrated that GABA(B2) was required for GABA(B1) to reach the cell surface. However, even a mutated GABA(B1) able to reach the cell surface is not functional alone despite its ability to bind GABA(B) ligands. This clearly demonstrated that GABA(B2) is not… CONTINUE READING
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