Activation mechanism of endothelin ETB receptor by endothelin-1

Abstract

Endothelin, a 21-amino-acid peptide, participates in various physiological processes, such as regulation of vascular tone, humoral homeostasis, neural crest cell development and neurotransmission. Endothelin and its G-protein-coupled receptor are involved in the development of various diseases, such as pulmonary arterial hypertension, and thus are important… (More)
DOI: 10.1038/nature19319

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