Activation mechanism of endothelin ETB receptor by endothelin-1

@article{Shihoya2016ActivationMO,
  title={Activation mechanism of endothelin ETB receptor by endothelin-1},
  author={Wataru Shihoya and Tomohiro Nishizawa and Akiko Okuta and Kazutoshi Tani and Naoshi Dohmae and Yoshinori Fujiyoshi and Osamu Nureki and Tomoko Doi},
  journal={Nature},
  year={2016},
  volume={537},
  pages={363-368}
}
  • Wataru Shihoya, Tomohiro Nishizawa, +5 authors Tomoko Doi
  • Published 2016
  • Chemistry, Medicine
  • Nature
  • Endothelin, a 21-amino-acid peptide, participates in various physiological processes, such as regulation of vascular tone, humoral homeostasis, neural crest cell development and neurotransmission. Endothelin and its G-protein-coupled receptor are involved in the development of various diseases, such as pulmonary arterial hypertension, and thus are important therapeutic targets. Here we report crystal structures of human endothelin type B receptor in the ligand-free form and in complex with the… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 80 CITATIONS, ESTIMATED 60% COVERAGE

    FILTER CITATIONS BY YEAR

    2017
    2020

    CITATION STATISTICS

    • 6 Highly Influenced Citations

    • Averaged 21 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 64 REFERENCES

    Endothelin system: the double-edged sword in health and disease.