Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction

@article{McCarty1998ActivationLT,
  title={Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction},
  author={Joseph H McCarty and Stuart C. Feinstein},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={1691-1700}
}
The TrkB receptor tyrosine kinase (RTK) is a high affinity receptor for the neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5). Following exposure to BDNF or NT-4/5, TrkB is autophosphorylated on five cytoplasmic tyrosines: Y484, Y670, Y674, Y675, and Y785. Based on crystallographic analyses for others RTKs, TrkB tyrosines Y670, Y674, and Y675 are expected to lie within a putative kinase activation loop. Phosphorylation of these activation loop tyrosines is… CONTINUE READING

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