Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

@article{Martn2002ActivationinducedCD,
  title={Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas},
  author={A. Mart{\'i}n and P. Bardwell and C. Woo and M. Fan and M. Shulman and M. Scharff},
  journal={Nature},
  year={2002},
  volume={415},
  pages={802-806}
}
The production of high-affinity protective antibodies requires somatic hypermutation (SHM) of the antibody variable (V)-region genes. SHM is characterized by a high frequency of point mutations that occur only during the centroblast stage of B-cell differentiation. Activation-induced cytidine deaminase (AID), which is expressed specifically in germinal-centre centroblasts, is required for this process, but its exact role is unknown. Here we show that AID is required for SHM in the centroblast… Expand
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