• DOI:10.1038/nature714
Corpus ID: 4349496

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

@article{Martn2002ActivationinducedCD,
  title={Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas},
  author={A. Mart{\'i}n and P. Bardwell and C. Woo and M. Fan and M. Shulman and M. Scharff},
  journal={Nature},
  year={2002},
  volume={415},
  pages={802-806}
}

• A. Martín, P. Bardwell, +3 authors M. Scharff
• Published 2002
• Biology, Medicine
• Nature

The production of high-affinity protective antibodies requires somatic hypermutation (SHM) of the antibody variable (V)-region genes. SHM is characterized by a high frequency of point mutations that occur only during the centroblast stage of B-cell differentiation. Activation-induced cytidine deaminase (AID), which is expressed specifically in germinal-centre centroblasts, is required for this process, but its exact role is unknown. Here we show that AID is required for SHM in the centroblast… Expand

View on Springer

ncbi.nlm.nih.gov

Save to Library

Create Alert

Cite

Launch Research Feed