Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers.

@article{Endo2008ActivationinducedCD,
  title={Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers.},
  author={Yoko Endo and Hiroyuki Marusawa and Tadayuki Kou and Hiroshi Nakase and Shigehiko Fujii and Takahiro Fujimori and Kazuo Kinoshita and T. Honjo and Tsutomu Chiba},
  journal={Gastroenterology},
  year={2008},
  volume={135 3},
  pages={889-98, 898.e1-3}
}
BACKGROUND & AIMS Activation-induced cytidine deaminase (AID) was originally identified as an inducer of somatic hypermutations in the immunoglobulin gene. We recently revealed that ectopic AID expression serves as a link between the cellular editing machinery and high mutation frequencies, leading to human cancer development. In the current study, we investigated whether AID might contribute to the development of colitis-associated colorectal cancers. METHODS The expression and regulation of… CONTINUE READING

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