Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.

@article{Hasham2012ActivationinducedCD,
  title={Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.},
  author={Muneer G Hasham and Kathy J. Snow and Nina M. Donghia and Jane A. Branca and Mark D. Lessard and Janet Stavnezer and Lindsay S. Shopland and Kevin D. Mills},
  journal={Journal of immunology},
  year={2012},
  volume={189 5},
  pages={2374-82}
}
Activation-induced cytidine deaminase (AID) initiates DNA double-strand breaks (DSBs) in the IgH gene (Igh) to stimulate isotype class switch recombination (CSR), and widespread breaks in non-Igh (off-target) loci throughout the genome. Because the DSBs that initiate class switching occur during the G₁ phase of the cell cycle, and are repaired via end joining, CSR is considered a predominantly G₁ reaction. By contrast, AID-induced non-Igh DSBs are repaired by homologous recombination. Although… CONTINUE READING