Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.

@article{Staszewski2011ActivationinducedCD,
  title={Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.},
  author={Ori Staszewski and Richard E. Baker and Anna J. Ucher and Raygene Martier and Janet Stavnezer and Jeroen E J Guikema},
  journal={Molecular cell},
  year={2011},
  volume={41 2},
  pages={232-42}
}
After immunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of immunoglobulin (Ig) genes in B cells, introducing mutations within the antigen-binding V regions (somatic hypermutation, SHM) and double-strand DNA breaks (DSBs) into switch (S) regions, leading to antibody class switch recombination (CSR). We asked if, during B cell activation, AID also induces DNA breaks at genes other than IgH genes. Using a nonbiased genome-wide approach, we have… CONTINUE READING
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