Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells.

@article{Muoz2013ActivationinducedCD,
  title={Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells.},
  author={Denise P. Mu{\~n}oz and Elbert Lan Lee and Sachiko Takayama and Jean-Philippe Copp{\'e} and Seok-Jin Heo and Dario Boffelli and Javier M Di Noia and David I. K. Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 32},
  pages={E2977-86}
}
Activation-induced cytidine deaminase (AID), which functions in antibody diversification, is also expressed in a variety of germ and somatic cells. Evidence that AID promotes DNA demethylation in epigenetic reprogramming phenomena, and that it is induced by inflammatory signals, led us to investigate its role in the epithelial-mesenchymal transition (EMT), a critical process in normal morphogenesis and tumor metastasis. We find that expression of AID is induced by inflammatory signals that… CONTINUE READING
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