Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor.

@article{Chhabra2006ActivationinducedCD,
  title={Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor.},
  author={Arvind Chhabra and Shikhar Mehrotra and Nitya G. Chakraborty and David I. Dorsky and Bijay Mukherji},
  journal={European journal of immunology},
  year={2006},
  volume={36 12},
  pages={3167-74}
}
Activation-induced cell death (AICD) of T cells can be an impediment towards achieving a robust and long-lived cytolytic T lymphocyte (CTL) response from active specific immunization or after adoptive cell transfer in cancer immunotherapy. The mechanism of AICD in primary CTL, however, remains poorly understood. It is widely believed that AICD is driven by signals from death receptors (DR) and that the cell death takes place in a caspase-dependent manner, although it has been shown that AICD of… CONTINUE READING

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