Activation-induced aggregation and processing of the human Fas antigen. Detection with cytoplasmic domain-specific antibodies.

@article{Kamitani1997ActivationinducedAA,
  title={Activation-induced aggregation and processing of the human Fas antigen. Detection with cytoplasmic domain-specific antibodies.},
  author={Tetsu Kamitani and Hoa Phuong Nguyen and Edward T. H. Yeh},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 35},
  pages={22307-14}
}
Fas (APO1/CD95) is a type 1 transmembrane protein critically involved in receptor-mediated apoptosis. Previous studies have shown that Fas exists in monomeric form in resting cells and aggregates upon cross-linking to form a complex that serves to recruit additional signaling molecules to the cell membrane. To study the molecular fate of the Fas antigen following receptor activation, a monoclonal antibody specific for the cell death domain of Fas has been generated. This monoclonal antibody… CONTINUE READING
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