Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation.

@article{Wrnmark2003ActivationF1,
  title={Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation.},
  author={Anette W{\"a}rnmark and Eckardt Treuter and Anthony P. H. Wright and Jan-{\AA}ke Gustafsson},
  journal={Molecular endocrinology},
  year={2003},
  volume={17 10},
  pages={
          1901-9
        }
}
Nuclear receptors (NRs) comprise a family of ligand inducible transcription factors. To achieve transcriptional activation of target genes, DNA-bound NRs directly recruit general transcription factors (GTFs) to the preinitiation complex or bind intermediary factors, so-called coactivators. These coactivators often constitute subunits of larger multiprotein complexes that act at several functional levels, such as chromatin remodeling, enzymatic modification of histone tails, or modulation of the… CONTINUE READING

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